DMT, Dimethyltryptamine, analogous to the neurotransmitter serotonin (5-HT) and other psychedelic tryptamines such as 5-MeO-DMT, bufotenin (5-OH-DMT), and psilocin (4-OH-DMT) is naturally produced in small amounts by the pineal gland in the brain and other tissues of humans and other mammals and also in plants. It’s one of the most illegal substances in the world. René Descartes, who dedicated much time to the study of the pineal gland, called it the "seat of the soul". He believed that it was the point of connection between the intellect and the body. Some evolutionary biologists believe that the vertebrate pineal cells share a common evolutionary ancestor with retinal cells. It’s literally a third eye. In some vertebrates, exposure to light can set off a chain reaction of enzymatic events within the pineal gland that regulate circadian rhythms. Some early vertebrate fossil skulls have a pineal opening. This correlates with the physiology of the modern "living fossils", the lamprey fish and the tuatara, a lizard species, and some other vertebrates that have a parietal organ or "third eye," which, in some of them, is photosensitive. The third eye represents evolution’s earlier approach to photoreception. The structures of the third eye in the tuatara are homologous to the cornea, lens and retina, though the latter resembles that of an octopus rather than a vertebrate retina. The asymmetrical whole consists of the "eye" to the left and the pineal sac to the right. "In animals that have lost the parietal eye, including mammals, the pineal sac is retained and condensed into the form of the pineal gland." In the Pineal gland, DMT is released during REM sleep and before death and it’s a major psychedelic trip.
According to Joe Rogan an American stand up comedian; " It's the craziest drug ever, it's the most potent psychedelic known to man. Literally, but the craziest thing about it; it's natural and your brain produces it every night as you sleep. You know, when you sleep, during the time you're in heavy REM sleep and right before human death, your brain pumps out heavy doses of Dimethyltriptamine. Nobody knows what sleeping is all about. Nobody knows why dreaming is important, but dreaming is hugely important; If you don't dream, you go crazy and you'll die. And while you are dreaming, when you're in heavy REM sleep, you are going through a psychedelic trip. Very few people know about this. It's been documented, there's a great book on it called "DMT the spirit molecule" by Dr Rick Strassman and he did all these clinical studies at the university of New Mexico on it. And if you take it, you're transported into another dimension. I don't mean like you feel like you're in an other dimension; I mean like you're IN an other dimension. An other dimension where there's no furniture bro, there's f'cking complex geometric patterns moving in synchronistic order through the air, all around you, in threedimensional space and it’s like there's arteries except there’s no blood pumping through them; there’s f'cking light, pulsating lights with no boundaries and you couldn't really understand it and there’s an alien communicating with you and he's a dude who looks like, like, sorta like a Thai Buddha except he's made entirely of energy and there's no, there's no like outline to him. He's just one thing... and he is concentrating on me and he's trying to tell me to not give in to astonishment. Just relax and try to experience this. And I'm like; You've got to be f'cking shitting me."
Several test subjects reported Near Death Experience-like audio or visual hallucinations. Several subjects also reported contact with 'other beings', alien like, insectoid or reptilian in nature, in highly advanced technological environments where the subjects were 'carried', 'probed', 'tested', 'manipulated', 'dismembered', 'taught', 'loved' and even 'raped' by these 'beings'.